I found an older episode of Ask Pastor John with a really important question: Can I really trust my interpretation of the Bible?
John Piper addresses the question from two angles. First, he offers guidance to the person looking for guidance. Second, he addresses the inconsistency of an extreme skeptical perspective.
I could give, for example, five biblical pointers to how the Bible says we should handle the law. And a certain kind of person could say to me, “But how do I know that I’m reading those pointers correctly?” And I could give an explanation of the pointers and how they work. They could say, “But how do I know that I’m interpreting your explanation correctly?”